World-wide epidemiology of HBeAg-negative chronic hepatitis B and associated precore and core promoter variants
نویسندگان
چکیده
منابع مشابه
World-wide epidemiology of HBeAg-negative chronic hepatitis B and associated precore and core promoter variants.
Hepatitis B is a serious disease that is endemic in many parts of the world. A significant proportion of patients with chronic hepatitis B (CHB) are infected with a variant form of the hepatitis B virus (HBV) which decreases or abolishes the production of hepatitis B e-antigen (HBeAg). The purpose of this literature review is to describe the epidemiology of HBeAg-negative CHB (e-CHB) worldwide....
متن کاملDeep sequencing of hepatitis B virus basal core promoter and precore mutants in HBeAg-positive chronic hepatitis B patients
Mutants in the basal core promoter (BCP) and precore (PC) regions of hepatitis B virus (HBV) genome are associated with the progression of chronic hepatitis B (CHB) infection. However, quasispecies characteristics of naturally occurring mutants in those regions in HBeAg-positive CHB patients has not been well described, partly limited by quantitative assay. This study aimed to develop an Ion To...
متن کاملHigh rate of core promoter and precore mutations in patients with chronic hepatitis B
BACKGROUND The prevalence of precore (PC) and core promoter (CP) mutations in patients with chronic hepatitis B virus (HBV) infection (CHB) and their impact on liver disease is incompletely defined in the United States. METHODS A retrospective chart review using a cross-sectional approach of 1,186 CHB patients was conducted. RESULTS Of 926 patients tested for HBV e antigen (HBeAg), 37% were...
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Objective(s): It has been reported that the mutation of the pre-core (PC) and basal-core promoter (BCP) may play an important role in the development of HBV-related hepatocellular carcinoma (HCC). In this study the PC and BCP mutations were investigated in chronic HBV patients. Materials and Methods:In this study, 120 chronic HBV patients from Golestan, Northeast of Iran who were not vaccinated...
متن کاملmutations of basal core promoter and precore regions in hepatitis b virus genotypes b and c
conclusions the mutation ratio difference between genotypes b and c in children was higher than that of adults and several combined mutations were exclusively detected in children with chronic hbv genotype c infection associated with higher viral load. objectives the aim of this study was to assess the mutation profiles of bcp and precore regions in different hbv genotypes in chronically infect...
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ژورنال
عنوان ژورنال: Journal of Viral Hepatitis
سال: 2002
ISSN: 1352-0504,1365-2893
DOI: 10.1046/j.1365-2893.2002.00304.x